Has ANC Had an Impact on Clinical Science? Yes, We Have

How do we know who has had deep vein thrombosis?

An attempt was made to identify all patients diagnosed as having deep vein thrombosis (DVT) in a large teaching hospital during one year. A review of the radiology records showed that 124 (81%) of the 154 venograms performed were for suspected DVT, and that the diagnosis was confirmed in 57 (46%). During the same period, the Hospital Activity Analysis (HAA) records revealed 174 episodes classif...

Brain fumes: yes, we have NO brain gas.

Nitric oxide (NO) is improbable as a conventional neurotransmitter. It is not an amine, amino acid, or peptide; it is not stored in synaptic vesicles or released by exocytosis; and it does not interact with specific receptor subtypes in neuronal membranes. However, NO is synthesized upon demand in the brain, diffuses to receptor sites within the enzyme guanylyl cyclase, and has neurotransmitter...

Yes, We Can! (Should We?).

Yes, We Have an Inflation of Reviews: But of the Wrong Kind!

I read with interest Ingo Schubert's short article on the inflationary number and value of review papers (Front. Plant Sci. 7:88. doi: 10.3389/fpls.2016.00088). I wholeheartedly agree with Schubert that far too many reviews are getting published. Many are what I call " catalog " reviews, and any good Ph.D student worth his salt can, with the help of PubMed, make a compilation of the recent (las...

Advocacy: yes we can.

It is an honor and privilege to address you as president of the American Society for Clinical Investigation. For more than 100 years, this organization has represented the best of physician-scientists. Since it is now 2012, there is the possibility that this could be the last ASCI presidential address. But we will assume the Mayans miscalculated and that we should look to the future. With the A...